Berlin 2018 – scientific programme

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BP: Fachverband Biologische Physik

BP 15: Postersession III

BP 15.3: Poster

Tuesday, March 13, 2018, 14:00–16:00, Poster B

Structural changes of lung surfactant Langmuir films in contact with compressed fluorocarbon gases — •Susanne Dogan, Michael Paulus, Julia Nase, Steffen Bieder, and Metin Tolan — Fakultät Physik/DELTA, TU Dortmund, 44221 Dortmund, Germany

Current lung surfactant (LS) replacements consist of purified preparations of bovine LS (Survanta) or porcine LS (Curosurf), which are not devoid of potential viral contamination and inherent immunological risks. Fluorocarbon gases (FCs) have been investigated for various biological applications. The results suggest that FCs may be useful in pulmonary disease therapy. Thus, substituting the current LS replacements by FCs might be reasonable. However, FCs are potentially harmful to membranes and thus [1, 2] the aim of this study is the determination of structural changes in Langmuir films in contact with FCs. The effect of the external gaseous phase of octafluoropropan and decafluorobutan on DPPC, the primary component of lung surfactant or the surfactants Curosur and Survanta was studied. Knowledge on the structural organisation and reorganisation of these amphiphilic molecules under gaseous pressure is essential for the understanding of the basic biological principles, which are present in medicine [3, 4]. X-ray reflectivity is the ideal to study different properties of a layer system at interfaces, such as layer thickness, roughness, and electron density with sub-Angström in-situ. [1] Giebel, F. et al. J. Appl. Phys., 2014 [2] Giebel, F. et al. Eng. Asp, 2016 [3] Amann, A. et al. Int. J. Mass Spectrom, 2004, [4] Zasadzinski, Curr. Opin. Col. In. Sci., 2001