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Berlin 2018 – scientific programme

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BP: Fachverband Biologische Physik

BP 15: Postersession III

BP 15.69: Poster

Tuesday, March 13, 2018, 14:00–16:00, Poster B

The effects of polar co-solutes on the hydration interaction between lipid bilayers — •Amanuel Wolde-Kidan1, Quoc Dat Pham2, Emanuel Schneck3, Emma Sparr2, and Roland Netz11Fachbereich Physik, Freie Universitaet Berlin, Arnimallee 14, 14195 Berlin, Germany — 2Division of Physical Chemistry, Chemistry Department, Lund University, P.O. Box 124, 22100 Lund, Sweden — 3Department of Biomaterials, Max-Planck Institute of Colloids and Interfaces, 17746 Postdam, Germany

The so-called hydration interaction between lipid bilayers has been studied intensively, but a fundamental explanation remains elusive until today. Using molecular dynamics simulations we analyse the effect of the addition of different polar co-solutes, namely TMAO, urea and sodium chloride, on the interaction between DMPC and POPC lipid bilayer stacks. From our simulations we can determine the water chemical potential, while gradually swelling our bilayer systems, to asses the strength of the hydration interaction. Results from the simulations have been confirmed by calorimetry experiments. We find that the hydration interaction in systems with polar co-solutes is a combination of the hydration interaction of the lipid bilayers in neat water and the interactions of the co-solutes within the water slab.

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