Berlin 2018 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 15: Postersession III

BP 15.71: Poster

Dienstag, 13. März 2018, 14:00–16:00, Poster B

Synchronization-based reconstruction of cardiac electrical wave dynamics from mechanical deformation — •Jan Lebert, Ulrich Parlitz, Stefan Luther, and Jan Christoph — Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany

The understanding of the mechanisms of heart rhythm disorders such as ventricular fibrillation is severely limited by the inability to experimentally observe the electrical activity within the heart muscle. From a dynamical systems viewpoint, heart muscle tissue is a non-linear, excitable, electromechanically coupled medium with a complicated anisotropic structure consisting of interconnected sheets of muscle fiber. Based on recent experimental observations of localized correlation between mechanical deformation of the heart and the electrical activity on its surface, we propose a novel approach for reconstructing cardiac wave dynamics. We utilize a technique called data assimilation to synchronize observations of the mechanical deformation with a computational model of excitable cardiac tissue coupled with an elastic mass-spring system for deformation modeling. Here, we demonstrate that our approach is able to reconstruct complex spatio-temporal cardiac electrical wave dynamics from simulation-generated surrogate observations of mechanical deformation. We show that the synchronization recovers the dynamics of the unobserved state variables from the excitable tissue model as well as the observed mechanical deformation.