Berlin 2018 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 15: Postersession III

BP 15.79: Poster

Dienstag, 13. März 2018, 14:00–16:00, Poster B

Non-equilibrium scaling behavior in driven soft biological networks — •Grzegorz Gradziuk, Federica Mura, and Chase Broedersz — Arnold-Sommerfeld-Center for Theoretical Physics and Center for NanoScience, Ludwig-Maximilians-Universität München, D-80333 München, Germany

Recent experiments indicate non-equilibrium activity in a host of biological systems, including chromosomes, cell membranes, and the cytoplasm. Measuring and quantifying non-equilibrium dynamics in such systems is a major challenge in biophysics, due to their many-body nature and the limited number of variables accessible in an experiment. We investigate what information concerning the system's non-equilibrium state can be extracted from non-invasive tracking of a subset of degrees of freedom. To this end, we develop a general, yet simple stochastic model of soft elastic networks with a heterogeneous distribution of internal activities, representing enzymatic force generation. Using this model, we determine the scaling behavior of non-equilibrium dynamics using the phase space currents of tracer particles with different spatial separations in the system. Our results provide insight in to how internal driving by enzymatic activity generates non-equilibrium dynamics on different length scales in a variety of biological systems, including polymers, membranes and networks.