Berlin 2018 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 15: Postersession III

BP 15.9: Poster

Dienstag, 13. März 2018, 14:00–16:00, Poster B

Effect of Membrane Mediated Forces on Protein Organization — •Henning Stumpf¹ and Ana-Sunčana Smith^1,2 — ¹PULS Group, EAM, Institute for Theoretical Physics I, Friedrich-Alexander University Erlangen-Nürnberg, Germany — ²Division of Physical Chemistry, Institute Ruđer Bošković, Zagreb, Croatia

Assembly of macromolecular complexes on membranes is a crucial step in many biological processes. For example, in cell adhesion, binding proteins need to be recruited to the site of contact. Recently, it has been suggested that membrane mediated interactions, through local changes in membrane composition, deformation and fluctuations, may induce long range attraction between proteins. To investigate these interactions we study membrane promoted aggregation of proteins that are modelled as harmonic springs, displacing the membrane and restricting membrane fluctuations. We calculate the forces between proteins in a mean field model and find a rich asymptotic behaviour depending on the membrane tension and bending stiffness. We use the second virial coefficient to determine under which conditions these interactions will lead to a change in local protein density. Furthermore, we study the effect of the aggregation on the transport coefficients of a protein. We find that in the relevant range of parameters, membrane mediated forces may have significant impact on protein diffusion.