Berlin 2018 – scientific programme

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BP: Fachverband Biologische Physik

BP 15: Postersession III

BP 15.93: Poster

Tuesday, March 13, 2018, 14:00–16:00, Poster B

Computational modeling of active membranes in flows — •Christian Bächer and Stephan Gekle — Biofluid Simulation and Modeling, Bayreuth, Germany

Active stresses induced by ATP-mediated processes within the cell cortex, can cause strong membrane deformations, which are highly important in blood platelet formation. In the framework of Lattice-Boltzmann/Immersed boundary method we numerically combine active cell membranes [1] and external flows, which have been experimentally found to strongly accelerate platelet formation [2]. Using differential geometry, we calculate the stresses within the curved, active membrane and the resulting forces onto the surrounding fluid. Membrane properties and forces are discretized on a triangulated thin shell coupled to the fluid. Forces of active origin are combined with shear and bending elasticity using Skalak and Helfrich model to cover realistic cell membrane behavior. Following blood platelet formation, we focus on instabilities of cylindrical shaped membranes under influence of external shear forces.

[1] G. Salbreux, F. Jülicher, Phys. Rev. E 96(3), 2017

[2] M. Bender et al., Blood 125(5), 2015