Berlin 2018 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 16: Membranes and Vesicles I (joint session BP/CPP)
BP 16.3: Vortrag
Mittwoch, 14. März 2018, 10:00–10:15, H 1028
Formation and Stabilization of Pores in Bilayer Membranes by Peptide-like Amphiphilic Polymers — •Ankush Checkervarty1,2, Marco Werner1,3, and Jens Uwe Sommer1,2 — 1Leibniz-Institute of Polymer Research Dresden, Hohe Strasse 6, 01069 Dresden, Germany — 2Institute of Theoretical Physics, Technische Universitat Dresden, Germany — 3Universitat Rovira i Virgili, Departament dEnginyeria Quimica, Av. Paisos Catalans 26, 43007 Tarragona, Spain
We study pore formation in models of lipid-bilayer membranes interacting with amphiphilic copolymers mimicking anti-microbial peptides using Monte Carlo simulations rationalized by a simple brush-model for the fluid membrane. In our study at least a weak tension on the membrane is required to observe pore-formation induced by the adsorption of flexible amphiphilic copolymers. The copolymers enhance the pore stability by decreasing the line tension due to weak adsorption along the rim of the pore. Pore formation is enhanced with increasing length of copolymers or stronger stretching of the membrane. Both solvent and copolymer permeability increase as the pore becomes stable. Pore-formation proceeds via a meta-stable pore-state according to adiscontinuous phase transition scenario which lead to finite pore-sizes at once. Our generic model of copolymer-induced pore-formation does not require high polymer concentration at the pores nor any self-organization of the copolymers to open the pore.