Berlin 2018 – wissenschaftliches Programm

Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe

BP: Fachverband Biologische Physik

BP 20: Statistical Physics of Biological Systems DY (joint session DY/BP)

BP 20.1: Vortrag

Mittwoch, 14. März 2018, 10:00–10:15, BH-N 333

Fluctuation effects in single-molecule dynamics: From sub-ergodic time-scales to the kinetics in the few-encounter limit — Alessio Lapolla, David Hartich, and •Aljaz Godec — Mathematical Biophysics Group, Max-Planck-Institute for Biophysical Chemistry (Göttingen)

Single-molecule (SM) dynamics evade the confines of traditional ensemble statistical mechanics. A correct theoretical description of SM dynamics requires a time-average statistical mechanics – the explicit consideration of trajectory-to-trajectory fluctuations over finite observation times. Similarly, a new paradigm emerges when considering molecular reaction kinetics in the few-encounter limit occurring, e.g. in transcription regulation or in diseases triggered by protein misfolding, where already the first reactive event is ’catastrophic’.

We will review our recent theoretical results on a rigorous formulation of occupation-time statistical mechanics, and a first passage time theory of few-encounter kinetics. We will discuss why our results are relevant for explaining quantitatively emerging biophysical phenomena at low-copy numbers.