Berlin 2018 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 22: Computational Biophysics II

BP 22.3: Vortrag

Mittwoch, 14. März 2018, 15:30–15:45, H 1058

Performing cell-based tissue simulations to explore the impact of cell mechanics on anisotropic epithelial tissue growth — •Anna Stopka and Dagmar Iber — D-BSSE, ETH Zürich, Schweiz

Understanding the anisotropic expansion of an embryonic tissue during organogenesis is a central challenge in developmental biology. Experimental studies increasingly provide quantitative data on cell behaviour during tissue growth. Computational models can help to interpret the acquired data and to infer underlying mechanisms. Our group has recently developed the 2D software framework LBIBCell to permit data-based simulations of tissue dynamics at cellular resolution [1]. LBIBCell represents cells as finely resolved polygons according to the Immersed Boundary (IB) method; membrane tension and cell-cell adhesion are represented via springs. The fluid behaviour inside and outside of the cells is described by the Lattice Boltzmann (LB) method. Cell growth is implemented via a fluid source inside the cells. Anisotropic outgrowth of epithelial tissues has been accounted to a range of mechanisms, including a bias in cell division orientation. We have used LBIBCell to investigate to what extent the mechanical properties of an epithelial tissue affect its capability to achieve anisotropic outgrowth via biased cell divisions. In our simulations we focused on the 2D apical plane where epithelial cells adhere tightly. We show that a bias in cell division orientation translates into a bias in outgrowth only for sufficiently stiff tissues. [1] S.Tanaka, D.Sichau, D.Iber, Bioinformatics (2015)