Berlin 2018 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 22: Computational Biophysics II
BP 22.5: Vortrag
Mittwoch, 14. März 2018, 16:15–16:30, H 1058
On how the CSF flows in the ventral third ventricle of brain — •Yong Wang1, Christian Westendorf1, Regina Faubel2, Gregor Eichele3, and Eberhard Bodenschatz1 — 1MPI for Dynamics and Self-Organization, 37077 Göttingen, Germany — 2Department of Developmental Biology, U Pittsburgh, Pittsburgh PA 15201, USA — 3MPI for Biophysical Chemistry, 37077 Göttingen, Germany
A complex transport network driven by coordinated motile cilia inside the ventral third ventricle (v3V) of mammalian brain was reported recently. This network generates cerebrospinal fluid (CSF) flow patterns such as a separatrix and a whirl that establish intraventricular boundaries. The CSF flow in the whole three-dimensional v3V cavity was studied numerically. Specifically, experimental trajectory data obtained by tracking fluorescent beads were converted to 2D velocity fields. The velocity maps were then refined by considering divergence-free and projected onto a curved virtual surface as boundary conditions. Three-dimensional flow features with likely physiological consequences were uncovered numerically. We thank the Max Planck Society for financial support. This work is conducted within the Physics and Medicine Initiative at Goettingen Campus between Max Planck Society and University Medicine Center.