Berlin 2018 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 24: Bioinspired Functional Materials, Biomaterials and Biopolymers (joint session CPP/BP)
BP 24.1: Vortrag
Mittwoch, 14. März 2018, 15:00–15:15, PC 203
Specific Ion Effects of Protein-Coated Au NPs: The Influence of Hydroxide Formation on Charge and Stability — •Jonas Schubert1,2, Andreas Fery1,2, and Munish Chanana3,4 — 1Department of Nanostructured Materials, Leibniz-Institut für Polymerforschung Dresden e. V. — 2Physical Chemistry of Polymer Materials, Technische Universita*t Dresden, D-01062 Dresden, Germany — 3Institute of Building Materials (IfB), ETH Zurich, 8093 Zurich, Switzerland — 4EMPA Dübendorf, 8600, Dübendorf, Switzerland.
When NPs are exposed to the environment, a protein corona is generated around the NPs. This changes the physicochemical properties of the NPs drastically, especially their colloidal stability, which is a key feature for discovering their bioavailability, toxicity and fate in the environment. In this work, the impact of the type of protein corona on the colloidal stability towards different ions was investigated by using three different proteins. Au NPs were coated with bovine serum albumin, beta-lactoglobulin and insulin and tested against different ions. The particles exhibited a highly pronounced and dissimilar optical response towards various heavy metal ions. The response of the Au@Protein NPs towards the different metal ions strongly depends on the protein coating of the NPs, but also on the specific metal ion and the generation of metal hydroxides. We discovered that the generation of metal hydroxides is the determining factor for the dissimilar colloidal stability of Au@Protein NPs and therefore plays an important and up to now neglected role in the interpretation of specific ion effects.