Berlin 2018 – scientific programme

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BP: Fachverband Biologische Physik

BP 27: Cell Mechanics II

BP 27.5: Talk

Thursday, March 15, 2018, 10:45–11:00, H 1028

The Mechanics of Vesicle Blebbing — •Sebastian Hillringhaus, Gerhard Gompper, and Dmitry A. Fedosov — Institute of Complex Systems, Forschungszentrum Jülich, Jülich, Germany

A broad range of in silico models, including liquid and viscoelastic drop models, has been introduced for simulating the complex mechanical properties of different cell types. These models are used to understand and quantify experimental measurements. In this work, we employ a coarse-grained cell model in two and three dimensions which incorporates the membrane properties similar to the RBC-model and an elastic inner mesh to include the cytoskeletal properties. The model is formulated in the framework of the dissipative particle dynamics simulation method. It is used to investigate cell-blebbing, which is observed in synthetic vesicles. Cell-blebbing describes the dissociation of the membrane from the inner network, in this case as result of inner stress. We analyze the influence of different parameters on the blebbing process and show that the occurrence of blebbing is a result of the instability of the connection between membrane and actin-network.