Berlin 2018 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 36: Cell Adhesion and Migration, Multicellular Systems II
BP 36.2: Vortrag
Freitag, 16. März 2018, 10:00–10:15, H 1028
Simultaneous Modeling of Random Crawling and Internal Polarization of Motile Amoeboid Cells — •Sergio Alonso1, Maike Stange2, and Carsten Beta2 — 1Department of Physics, Universitat Politecnica de Catalunya, Barcelona, Spain — 2Institute of Physics and Astronomy, Universität Potsdam, Potsdam, Germany
The amoeboid motion of certain cells gives rise to different dynamics depending on the level of starvation. This motion is correlated with the patterns of diverse biochemicals in the interior of the cells. We compare first the displacement and the velocity of vegetative and starving cells of Dictyostelium discoideum with a simple model of individual cells. Second, the deformations of the membrane is studied in the numerical model and in the living cells, and finally, we study the patterns originated in the interior of the simulated cells and compare them with the actin patterns observed in the experiments. Therefore, we fit and adapt the parameter values of the model to correctly account for the motion of the centre of mass of the cell and the intracellular pattern formation.