Berlin 2018 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 6: Cytoskeletal Filaments I
BP 6.1: Vortrag
Montag, 12. März 2018, 15:00–15:15, H 1058
Glassy Dynamics in Composite Biopolymer Networks — •Tom Golde1, Constantin Huster1, Martin Glaser1,2, Tina Händler1,2, Harald Herrmann3,4, Josef A. Käs1, and Jörg Schnauß1,2 — 1University of Leipzig, Leipzig, Germany — 2Fraunhofer IZI, Leipzig, Germany — 3German Cancer Research Center, Heidelberg, Germany — 4University Hospital Erlangen, Erlangen, Germany
The cytoskeleton is a highly interconnected meshwork of strongly coupled filament systems providing mechanical stability as well as dynamic functions to cells. To elucidate the underlying biophysical principles it is central to investigate not only one distinct functional subsystem but rather their interplay as composite biopolymer structures. Here, we show that composite networks of actin and vimentin filaments can be fully described by a superposition of two non-interacting scaffolds. We demonstrate arising effects in a scale-spanning frame connecting single filament dynamics to macro-rheological network properties and show that linear and non-linear bulk mechanics of actin and vimentin filament networks are captured within the glassy wormlike chain model. Our findings clearly disagree with previous studies reporting emergent effects in these composite networks. These new insights pave the way to deterministically predict the mechanics of the cytoskeleton in distinct cell types based on the properties of its single structural components.[1]
[1] Golde et al., Submitted