Berlin 2018 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 6: Cytoskeletal Filaments I

BP 6.4: Hauptvortrag

Montag, 12. März 2018, 15:45–16:15, H 1058

Broken detailed balance in active biopolymer assemblies — •Chase Broedersz — Ludwig-Maximilians-Universitaet München, Munich, Germany.

We present a non-invasive approach to identify and quantify non-equilibrium dynamics in living systems based on broken detailed balance. With this approach, we study the dynamics of beating flagella, primary cilia, and cytoskeletal networks. In particular, we use stochastic time traces of the system's dynamics to infer the probability currents in a phase space of the mesoscopic configurational coordinates of a biological assembly. In addition, we will present a more general theoretical framework to investigate what information about the system's non-equilibrium state can be extracted from such phase space currents. For example, we will discuss how to extract the entropy production rate - a measure of the dissipated power in a driven system - from measured current cycles. Next, we present predictions for the scaling behavior of the entropy production rate with the distance between measurement points in the system. Our results provide insight in to how internal driving by enzymatic activity generates non-equilibrium dynamics on different scales in a variety of biological systems, including biopolymers and their assemblies.