Berlin 2018 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 9: Postersession I
BP 9.35: Poster
Montag, 12. März 2018, 17:30–19:30, Poster A
Self-Assembled Protein Hybrid Nanofibres — •Christian Helbing1, Tanja Deckert-Gaudig2, Gang Wei3, Volker Deckert2, and Klaus D. Jandt1 — 1Chair of Materials Science, Otto-Schott-Institute of Materials Research, Faculty of Physics and Astronomy, Friedrich Schiller University Jena, Germany — 2Institute for Photonic Technology, Jena, Germany — 3Hybrid Materials Interfaces Group, Faculty of Production Engineering, University of Bremen, Germany
Over the last years, the interest in materials consisting of biomolecules arranged in nanofibers increased. There is a special focus on plasma proteins for applications in nanofiber materials because of their high biocompatibility. An easy feasible strategy to create these nanofibers is the self-assembly mechanism of protein molecules. Here we test the hypothesis that novel self-assembled hybrid protein nanofibers (PNF) can consist of two different proteins. In this work, we present self-assembled plasma hybrid PNF consisting of two different plasma proteins. Further, long-time CD-measurements provide information about the fiber formation dynamics. Especially, for the PNNF hybrid it confirmed interactions between both molecules. We confirmed the existence of a novel PNF hybrid by tip enhanced Raman spectroscopy and immunolabeling. Also, differences in the mechanical behaviour were shown by force spectroscopy. These results lay the foundation for a novel biomaterial based on these (h)PNNFs.