Berlin 2018 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 9: Postersession I
BP 9.38: Poster
Montag, 12. März 2018, 17:30–19:30, Poster A
Clocks and timers in genetic networks. — •Jose Negrete JR1,2, Ivan M. Lengyel1,3, Laurel A Rohde2, Andrew C. Oates2, and Frank Jülicher1 — 1Max Planck Institute for the Physics of Complex Systems, Dresden, Germany — 2École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland — 3Instituto de Investigación en Biomedicina de Buenos Aires CONICET of, Argentina
Genetic oscillations are noisy and in many cases, as in embryo development, short lived. We present a model of a noisy transcription factor that controls the timing and amplitude of an stochastic genetic oscillator. The transcription factor determines how long the oscillator is on and it is denominated as a timer, while the genetic oscillator is denominated as a clock due to its repetitive nature. The model is given by a single delay differential equation, and we show analytically the set of measurable parameters that characterises it. The predictions of the model were tested by analysing two different cases: self sustained genetic oscillations from cycardian rhythms and in the transient oscillatory gene expression from cells extracted from the presomitic mesoderm of zebrafish embryos.