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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 12: Focus: Molecularly Functionalized Low-Dimensional Systems II - organized by Antonio Setaro, Carola Meyer, Aravind Vijayaraghvan and Matteo Mannini

CPP 12.6: Vortrag

Montag, 12. März 2018, 16:45–17:00, C 130

Nanowire field-effect transistor structures for the detection of cardiac biomarkers: troponin and C-reactive protein — Yurii Kutovyi, Ihor Zadorozhnyi, Volodymyr Handziuk, Hanna Hlukhova, Nazarii Boichuk, and •Svetlana Vitusevich — Bioelectronics (ICS-8), Forschungszentrum Juelich, 52425 Juelich, Germany

Today high-speed operation is one of the key factors in the development of biosensors. Cardiac disease is one of the most critical diseases, requiring medical treatment within the first two hours of acute myocardial infarction (AMI). Cardiac troponin (cTn) remains the gold standard in AMI diagnosis. cTn is released from the cardiac cell and its concentration typically increases after the onset of AMI. At the same time, C-reactive protein (CRP) can be used as a predictive biomarker to indicate the likelihood of AMI in the near future. In this presentation, we will discuss the design and fabrication of silicon nanowire field-effect transistor structures using CMOS-compatible technology as well as the results we obtained upon the detection of both proteins. We demonstrate that along with the threshold voltage shift measured as a function of charged molecule binding events, a number of new parameters due to single-trap phenomena can be used as the detection signal. Together with a gate coupling effect, the utilization of new parameters allows more sensitive monitoring of troponin and CRP behavior in addition to the realization of real-time compact devices for point-of-care applications. Authors gratefully acknowledge the Innovation Award RWTH transparent 2016.