Berlin 2018 – scientific programme
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 12: Focus: Molecularly Functionalized Low-Dimensional Systems II - organized by Antonio Setaro, Carola Meyer, Aravind Vijayaraghvan and Matteo Mannini
CPP 12.7: Talk
Monday, March 12, 2018, 17:00–17:15, C 130
Ultrasensitive and selective detection of biomarkers with bio-functionalized graphene field effect transistors — •David Kaiser1, Nikolaus Meyerbroeker2, Werner Purschke3, Andreas Winter1, Christof Neumann1, Thomas Weimann4, Albert Schnieders2, Axel Vater3, and Andrey Turchanin1 — 1Institute for Physical Chemistry, Friedrich Schiller University Jena, 07743 Jena, Germany — 2CNM Technologies GmbH, 33607 Bielefeld, Germany — 3APTARION biotech AG, 10589 Berlin, Germany — 4Physikalisch-Technische Bundesanstalt, 38116 Braunschweig, Germany
Due to the unique properties of graphene, graphene-based field effect transistors (GrFETs) are promising electronic devices for sensing of biological molecules. In this contribution, we present a concept of novel hybrid BioGrFETs for selective and ultrasensitive detection of biomarkers based on graphene functionalized non-covalently with L-aptamers via a molecular carbon nanomembrane (CNM). We demonstrate that the engineered BioGrFETs have up to 3 orders of magnitude dynamic range and reach a sensitivity limit down to 1 pM for selected biomarkers. We characterize the subsequent fabrication steps on the nanoscale by surface science and biochemical techniques and describe the BioGrFETs transfer characteristics by an electrochemical model of the heterostructure interface.