Berlin 2018 – wissenschaftliches Programm

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 20: Poster Session I

CPP 20.18: Poster

Montag, 12. März 2018, 17:30–19:30, Poster A

Morphological study of drug delivery systems based on poly(2-oxazoline) bottle brushes — •Kaltrina Shehu¹, Jia-Jhen Kang¹, Clemens Sachse², Rainer Jordan², and Christine M. Papadakis¹ — ¹TU München, Physik-Department, Garching, Germany — ²TU Dresden, Professur für Makromolekulare Chemie, Dresden, Germany

Nano carriers for drug delivery have traditionally been based on the self-assembly of amphiphilic block copolymers. These typically form spherical micelles which can incorporate hydrophobic drugs. It has been shown, however, that it is an advantage if the polymeric nanoparticles are elongated. Densely grafted copolymers, or polymeric bottle brushes, form unimolecular elongated nanoparticles. If their side arms are amphiphilic, they may incorporate hydrophobic drugs. Poly(2-oxazoline)s are highly biocompatible and may be rendered hydrophilic or hydrophobic by the choice of the side group, and are thus of interest for this application. Here, we investigate the concentration and temperature-dependent size, shape and inner structure of a polymeric bottle brush, having a poly(2-isopropenyl-2-oxazoline) backbone and poly(2-ethyl-2-oxazoline) side chain in dilute aqueous solution using dynamic light scattering (DLS) and small angle X-ray scattering (SAXS).