Berlin 2018 – scientific programme
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 32: Poster Session II
CPP 32.7: Poster
Tuesday, March 13, 2018, 14:00–16:00, Poster B
Ugi four-component reaction as versatile tool for multifunctional polysaccharide microgel fabrication — •Nicolas Hauck1, Nalin de Seixas Borges2, Ludger Wessjohann2, Andreas Fery1, and Julian Thiele1 — 1Leibniz-Institut für Polymerforschung Dresden e.V., Dresden, Germany — 2Leibniz-Institut für Pflanzenbiochemie, Halle, Germany
Polysaccharide-based microgels are of special interest in cell biology, tissue engineering, drug delivery, and cell-free biotechnology. However, hydrogel synthesis from polysaccharides often requires pre-functionalization of respective building blocks for subsequent crosslinking as well as for introducing other functionalities. In this context, it is particularly disadvantageous that conventional polymer-analogous coupling reactions often cannot simply be applied on polysaccharides due to an insufficient degree of functionalization. Thus, additional, time-consuming synthesis steps have to be afforded, before polysaccharide-based materials can be processed into defined microgels.
To address these challenges, we utilize multicomponent reactions, which allow for functionalization, e.g. with bioactive compounds or fluorescent dyes, and crosslinking of hydrogel precursors in parallel without time-consuming pre-modifications of precursors. Especially, the Ugi four component reaction is well suited for that purpose. Based on carboxylic acid-rich hyaluronic acid and a diamine as bifunctional crosslinker, hydrogels can be crosslinked with different functional aldehydes and isocyanides in situ to yield multifunctional microgels.