Berlin 2018 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 33: Poster Session III
CPP 33.39: Poster
Dienstag, 13. März 2018, 14:00–16:00, Poster C
Tailoring thermal properties of biodegradable polyester based nanoparticles for drug delivery — •Christian Helbing1, Damiano Bandelli2,3, Christine Weber2,3, Ulrich S. Schubert2,3, and Klaus D. Jandt1,3 — 1Chair of Materials Science, Otto-Schott-Institute of Materials Research, Friedrich Schiller University Jena, Germany — 2Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Germany — 3Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Germany
According to literature reports, the thermal properties of biodegradable polyesters influence their degradation and hence the release kinetics of actives from corresponding nanoparticles (NP). However, factors such as the hydrophilic / hydrophobic balance (HHB) and the drug loading impact release kinetics as well. We therefore tailor-made polyester based NPs with different thermal properties but constant HHB and size, as confirmed by means of dynamic light scattering and scanning electron microscopy. The NP are composed of a) poly(ε-caprolactone), b) block and c) gradient copolymers of δ-valerolactone and δ-decalactone. Differential scanning calorimetry measurements revealed semicrystalline materials with a significantly lowered melting temperature and degree of crystallinity of P(VL-grad-DL). Atomic force microscopy revealed that the NP stiffness correlates with the degree of crystallinity of the used polymer. This work is part of the Collaborative Research Center 1278 "Polytarget: Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies" which is funded by the DFG.