Berlin 2018 – scientific programme
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 33: Poster Session III
CPP 33.6: Poster
Tuesday, March 13, 2018, 14:00–16:00, Poster C
Soft X-ray analysis of microgels and polymer-based microcontainers in aqueous environment — •Andreas Späth1, George Tzvetkov2, Gaio Paradossi3, and Rainer H. Fink1 — 1Friedrich-Alexander Universität Erlangen-Nürnberg, Lehrstuhl für Physikalische Chemie II and ICMM, Erlangen, Germany — 2University of Sofia, Department of Inorganic Chemistry, Sofia, Bulgaria — 3Universita di Roma Tor Vergata, Dipartimento di Scienze e Tecnologie Chimiche, Rome, Italy
Polymer-based microgel and core-shell particles are versatile containers for the transport of drugs, theranostic gases or catalytically active molecules. They are in many cases biodegradable and fully compatible to in-vivo applications. During recent years we have investigated a broad range of such hybrid materials ranging from gas filled microballoons and thermoresponsible microgel networks to magnetoresponsive particles with embedded iron nanoparticles and core-shell systems filled with theranostic gases or catalytically active fluids. Soft X-ray microscopy is an excellent tool to study those systems in-situ in aqueous matrix with high-resolution and chemical sensitivity. We have analyzed shell thicknesses, swelling behaviors and temperature response to contribute better understanding on release mechanisms and have developed procedures to derive high-resolution 3D representations of the particles from 2D transmission micrographs. The project is funded by the BMBF (05K16WED).