Berlin 2018 – scientific programme
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 37: Focus: Smart Hydrogels and Hydrogel Based Devices II - organized by Gerald Gerlach, Walter Richtering and Thomas Hellweg
CPP 37.2: Talk
Wednesday, March 14, 2018, 10:00–10:15, C 130
Vapor-deposited Thin Hydrogel Coatings for Controlled Drug Release — Stephan Tumphart1,2, •Paul Christian1, Anna Coclite1, and Oliver Werzer2 — 1Inst. f. Solid State Physics, Graz University of Technology, Austria — 2Pharm. Tech. & Biopharmacy, University of Graz, Austria
Polymers can have a wide range of applications in the field of pharmaceutical formulation but are most often employed for controlled release behavior. "Smart polymers", meaning polymers that change chemical and physical properties depending on the environment they are in, are particularly interesting as they allow for a targeted release. However, the preparation of thin & defined polymer coatings atop of drug layers is usually difficult by common solution techniques. Initiated Chemical Vapor Deposition (iCVD), a solvent-free polymerization technique, is a powerful tool to conformally prepare thin polymer layers even on delicate substrates. In this study, the release behavior of model pharmaceuticals such as Indomethacin and Clotrimazole is investigated when coated either with a hydrogel or with a thermally-responsive polymer (NIPAAm). Depending on mesh size, polymer and temperature, the release behavior could be varied between several orders of magnitude.