Berlin 2018 – wissenschaftliches Programm

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 43: Membranes and Vesicles I (joint session BP/CPP)

CPP 43.1: Vortrag

Mittwoch, 14. März 2018, 09:30–09:45, H 1028

Actin polymerization driving localized membrane deformation — •Remy Kusters¹, Camille Simon¹, Jean-Francois Joanny^1,2, Cecile Sykes¹, and Pierre Sens¹ — ¹Institut Curie, Paris, France — ²ESPCI, Paris, France

The actin cytoskeleton is able to exert both pushing and pulling forces on the cell membrane, mediating processes such as cellular motility, endocytosis and cytokinesis. In order to investigate the exclusive role of actin dynamics on membrane deformations, the actin dynamics is reconstituted on the outer surface of a deformable liposome. Depending on the elasticity of the membrane and the forces generated by the actin polymerization, both tubular extrusions (i.e. towards the actin cortex) and localized spike-like protrusions occur along the surface of the liposome. In this talk I present a theoretical model where uniform actin polymerization can drive localized membrane deformations and show how polymerization kinetics and membrane/cortex mechanics impact their size and stability.