Berlin 2018 – wissenschaftliches Programm
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DY: Fachverband Dynamik und Statistische Physik
DY 15: Nonlinear Dynamics, Synchronization, Chaos I
DY 15.4: Vortrag
Montag, 12. März 2018, 16:15–16:30, BH-N 128
Synchronization of Viscoelastically Coupled Excitable Oscillators with Excitation-Contraction Coupling — •Florian Spreckelsen1,2, Ulrich Parlitz1,2,4, and Stefan Luther1,2,3,4,5 — 1Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany — 2Institute for Nonlinear Dynamics, Georg-August-Universität Göttingen, Germany — 3University Medical Center Göttingen (UMG), Institute of Pharmacology and Toxicology, Göttingen, Germany — 4DZHK (German Center for Cardiovascular Research), Partner Site Göttingen, Germany — 5Department of Physics and Department of Bioengineering, Northeastern University, Boston, USA
Viscoelastically coupled excitable oscillators are used to model individually beating spatially separated cardiomyocytes surrounded by an extra-cellular matrix (ECM) of collagen. This corresponds to the early states in the development of engineered heart muscle (EHM). Synchronization of the beating of the cardiomyocytes is necessary for functioning of EHM. We investigate how mechanical coupling via the ECM can synchronize two excitable oscillators with excitation contraction coupling and electromechanical feedback and how this synchronization depends on the rheological properties of the ECM.