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DY: Fachverband Dynamik und Statistische Physik

DY 70: Poster: Flows, Patterns, Delay, Reaction Diffusion

DY 70.10: Poster

Donnerstag, 15. März 2018, 15:30–18:00, Poster A

Magnetophoretic Lab-on-a-Chip system for biomolecular interaction analysis — •Hai Hoang¹, Özge Efendi², Meike Reginka¹, Daniela Bertinetti², Dennis Holzinger¹, Friedrich W. Herberg², and Arno Ehresmann¹ — ¹Institute of Physics, Center for Interdisciplinary Nanostructure Science and Technology (CINSaT), University of Kassel, Heinrich-Plett-Str. 40, D-34132 Kassel — ²Institute of Biology, Center for Interdisciplinary Nanostructure Science and Technology (CINSaT), University of Kassel, Heinrich-Plett-Str. 40, D-34132 Kassel

Lab-on-a-Chip (LOC) systems are promising devices for point-of-care technologies in biomedicine. Using a microfluidic system in combination with a remotely controllable transportation system of functionalized superparamagnetic beads can increase the detection limit of biomarkers (e.g. proteins) in body fluids. In a first step, the green fluorescent protein (GFP) was used as a model protein. For the LOC approach superparamagnetic beads functionalized with a GFP-specific binder are used for directed transport of GFP and GFP accumulation whereby channel design, mixing of fluids by bead movement and flow speed of the GFP-solution perpendicular to the bead movement are taken into consideration. The investigation of the system is done via optical and fluorescence microscopy as well as tracking and image analysis techniques.