Berlin 2018 – wissenschaftliches Programm
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MA: Fachverband Magnetismus
MA 33: Biomedical and molecular magnetism
MA 33.10: Vortrag
Mittwoch, 14. März 2018, 17:30–17:45, H 1012
Magnetite-gold Janus nanoparticles as all-in-one theranostics agents — •Maria V. Efremova1,2, Yulia A. Nalench2, Victor A. Naumenko2, Maxim A. Abakumov3, Marina Spasova4, Michael Farle4, Alexander G. Majouga1,2,5, Ulf Wiedwald2,4, and Natalia L. Klyachko1,2 — 1MSU, Moscow, Russia — 2NUST MISIS, Moscow, Russia — 3RNRMU, Moscow, Russia — 4UDE, Duisburg, Germany — 5MUCTR, Moscow, Russia
High-quality, 25 nm octahedral-shaped Fe3O4 magnetite nanocrystals are epitaxially grown on 9 nm Au seed nanoparticles (NPs) using a modified wet-chemical synthesis. Detailed studies of the structure and magnetism discover single-crystalline, nanosized Fe3O4 NPs with bulk-like magnetic properties (saturation magnetization of 86 Am2/kg at 300 K close to the bulk value of 92 Am2/kg and a Verwey transition from monoclinic to the cubic inverse spinel structure at TV = 123 K). For MRI, these features lead to their high T2-relaxivity in in vitro and in vivo experiments. We evaluate an at least doubled relaxivity as compared to the maximum values obtained for Fe3O4−Au hybrids and a 3-5 times higher value as compared to commercial T2 contrast agents in medical use. Moreover, first experiments on the magneto-mechanical action of the hybrid NPs in a low-frequency alternating magnetic field leads to a cell death rate of up to 44% compared to the control.
This work was supported by RFBR 17-54-33027 grant and Increase Competitiveness Programs of NUST MISiS K2-2016-069 (synthesis of nanomaterials) and K3-2017-022 (magnetic measurements).