Erlangen 2018 – scientific programme
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MO: Fachverband Molekülphysik
MO 2: Biology Related Molecules
MO 2.8: Talk
Monday, March 5, 2018, 12:15–12:30, PA 1.150
Spatially separated conformers of the dipeptide Ac-Phe-Cys-NH2 — •Nicole Teschmit1,2,3, Karol Długołȩcki1, Daniel Gusa1, Igor Rubinsky1, Daniel A. Horke1,2, and Jochen Küpper1,2,3,4 — 1Center for Free-Electron Laser Science, DESY, Hamburg, Germany — 2The Hamburg Center for Ultrafast Imaging, Universität Hamburg, Germany — 3Department of Chemistry, Universität Hamburg, Germany — 4Department of Physics, Universität Hamburg, Germany
The conformational separation of biomolecules in the gas phase is an important step toward atomic-resolution diffraction experiments, attosecond dynamics experiments, or kinetic studies of the chemical reactivity of a single conformer.
Here, we present the combination of a laser desorption (LD) source for the vaporization of labile biological molecules [1] with electrostatic control for the spatial separation of conformers [2]. We now demonstrate the conformer separation of the prototypical peptide Ac-Phe-Cys-NH2. We detail the characterization and optimization of LD beams, the use of strong field ionization as an universal probe, and the preparation of conformer-pure beams of the Ac-Phe-Cys-NH2 dipeptide. We analyze options for diffractive imaging of these controlled samples.
[1] N. Teschmit, K. Długołȩcki, D. Gusa, I. Rubinsky, D. A. Horke, J. Küpper, J. Chem. Phys. 147, 144204 (2017)
[2] Y.-P. Chang, D. A. Horke, S. Trippel, J. Küpper, Int. Rev. Phys. Chem. 34, 557 (2015)