Erlangen 2018 – scientific programme

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MS: Fachverband Massenspektrometrie

MS 6: Accelerator Mass Spectrometry 2

MS 6.2: Talk

Thursday, March 8, 2018, 11:00–11:15, R 1.020

Design of a new Gas Interface for biomedical ¹⁴C analyses — •Daniele De Maria¹, Simon Fahrni², Lukas Wacker¹, and Hans-Arno Synal¹ — ¹Laboratory of Ion Beam Physics, ETH Zurich, Switzerland — ²Ionplus AG, Dietikon, Switzerland

Radiocarbon analyses by accelerator mass spectrometry (AMS) have a great potential for biomedical applications, in particular in pharmacokinetic studies using ¹⁴C as a microtracer. Thus, the AMS approach for this research field was investigated in a validation study conducted in collaboration with Novartis (Basel, Switzerland) to evaluate the performance of the MICADAS. Since these studies require the measurement of a large number of samples in a short period of time, a key problem of AMS technology is its low sample throughput. Therefore, our aim is to develop a new gas handling system to achieve a faster measurement process for applications where low precision but higher throughput is required. The design of the new interface will be presented, focusing in particular on the strategies to overcome the time consuming cleaning procedure required after each sample to avoid cross-contamination.