Würzburg 2018 – wissenschaftliches Programm
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ST: Fachverband Strahlen- und Medizinphysik
ST 1: Radiation Therapy
ST 1.5: Vortrag
Montag, 19. März 2018, 17:00–17:15, Phys-HS P
Highly Efficient Laser Ionization of Lanthanides for Medical Radioisotope Production — •Vadim Gadelshin1, Roberto Formento Cavaier2,3,4, Ferid Haddad4, Tom Kieck1, Thierry Stora5, Dominik Studer1, Felix Weber1, Ilyes Zahi2, and Klaus Wendt1 — 1Johannes Gutenberg-Universität Mainz — 2Advanced Accelerator Applications, France — 3SUBATECH, Nantes University, France — 4GIP ARRONAX, France — 5CERN, Switzerland
Medical radioisotope production is a non-trivial high-tech challenge, regarding preparation and provision of a radioactive material as well as the purity of a final radiopharmaceutical. These aspects are of particular relevance for the innovative theranostics approach, in which radiotherapy and diagnostics are carried out with the same medicine.
At the CERN-MEDICIS facility novel theranostics radionuclides are generated. By bombardment of a target with high-energetic 1.4 GeV proton beam, myriads of different radioisotopes are produced. Subsequently, the element-selective mass separation is mandatory. The first batch of medical radiolanthanides has been recently demonstrated with the dedicated mass separator. In combination with element-selective multi-step laser resonant ionization, a highly efficient extraction and isotopic purity against radioactive cross contamination can be ensured.
In this talk, laser resonance ionization spectroscopy on the most promising lanthanides, i.e. terbium, erbium and lutetium, is presented. The concept of the laser lab "MELISSA" for MEDICIS facility is derived, and a possibility of transfer and application of this technology at commercial medical cyclotrons is studied.