München 2019 – wissenschaftliches Programm
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SYPP: Symposium Pulsed Power für Medizin und Biotechnologie
SYPP 1: Pulsed Power für Medizin und Biotechnologie I
SYPP 1.4: Hauptvortrag
Donnerstag, 21. März 2019, 12:15–12:45, HS 3
Calcium electroporation - a novel, low-cost anti-cancer treatment — •Stine Krog Frandsen1 and Julie Gehl1,2 — 1Department of Clinical Oncology and Palliative Care, Zealand University Hospital, Roskilde, Denmark — 2Department of Clinical Medicine, University of Copenhagen, Denmark
Calcium electroporation is a potential novel anti-cancer treatment where supraphysiological calcium concentrations are introduced into cells by electroporation, a method where short, high voltage pulses induce a transient permeabilisation of the plasma membrane allowing passage of ions and molecules into the cytosol. Calcium electroporation efficiently induce cell death in vitro and tumor necrosis in vivo (1). The first clinical trial showed that calcium electroporation is efficient on cutaneous metastases (2). The mechanism is associated with ATP depletion, and normal cells are less affected than malignant cells in vitro and in vivo (1). This difference in sensitivity might be due to differences in the expression of calcium transporters and differences in the cytoskeleton organization. Interestingly, it has recently been shown that calcium electroporation induces a systemic response in vivo (3) and in the clinical trial (4). Calcium electroporation is an efficient and simple, novel anti-cancer treatment that can easily be implement in the clinic. Recent studies indicate that this local treatment also induces a systemic immune response.
1. Frandsen, et al. Cancer Res. 2017. 2. Falk, et al. Acta Oncol. 2017. 3. Falk, et al. Oncoimmunology. 2017. 4. Falk, et al. Acta Oncol. 2017.