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BP: Fachverband Biologische Physik
BP 12: Poster II
BP 12.15: Poster
Tuesday, April 2, 2019, 14:00–16:00, Poster B2
Nanomorphology of living sinus nodal cells — •Max Ulbrich1, Mirco Wendt1, Julia J. Jung2, Christian Völkner1, Regina Lange1, Heiko Lemke2, Christian Rimmbach2, Robert David2, Ingo Barke1, and Sylvia Speller1 — 1Institute of Physics, University of Rostock, 18051 Rostock — 2Reference and Translation Center for Cardiac Stem Cell Therapy, University Medical Center Rostock, 18057 Rostock
Cardiomyocytes exhibit electro-mechanical activity and may therefore be envisioned as sensor or actuator cells. Sinus nodal cells form the pacemaker of the heart and exhibit autonomous activity while working myocardial cells follow their pace. In our studies, we use scanning ion conductance microscopy (SICM) [1] to observe the live-cell morphology and surface dynamics of individual sinus nodal cardiomyocytes derived by forward programming of pluripotent stem cells [2]. Here, we focus on the question whether the sinus nodal cell subtype exhibits characteristic features on its surface which can help to conclude on their origin as well as functionality.
[1] C-C Chen et al., Annu. Rev. Anal. Chem. 5, 207 (2012)
[2] J.J. Jung et al., Stem Cell Rep. 2, 592 (2014)