Regensburg 2019 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 12: Poster II

BP 12.46: Poster

Dienstag, 2. April 2019, 14:00–16:00, Poster B2

Influencing liposome structure by terpenoids: a TEM analysis — •Bernhard Kaltschmidt, Inga Ennen, Daniela Ramermann, and Andreas Hütten — Thin Films & Physics of Nanostructures, University of Bielefeld, Bielefeld, Germany

Today, multiresistant bacteria are more and more common in hospitals.Therefore the development of novel treatments is mandatory. Terpenoids are plant substances with antimicrobial activity. A new approach is to use the antibacterial properties of terpenoids as therapeutics. Since most terpenoids are insoluble in water, here we dissolved them in EtOH and used liposomes as carriers. Liposomes are nanoscale spherical vesicles, which were produced with an extruder and then analysed by Cryo transmission electron microscopy (Cryo-TEM). Different approaches were tested to determine the best imaging parameters. As terpenoids 1,8 cineol, campher, menthol and thymol of pharmaceutical grade were used. Cryo-TEM revealed a gradient of multi-lamellar liposomes to unilamellar liposomes. The highest antibacterial activity could be shown by thymol.