Regensburg 2019 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 14: Cell mechanics I
BP 14.7: Vortrag
Mittwoch, 3. April 2019, 11:30–11:45, H10
Numerical-experimental observation of shape bistability of red blood cells flowing in a microchannel — Achim Guckenberger1, Alexander Kihm2, Thomas John2, Christian Wagner2, and •Stephan Gekle1 — 1Biofluid Simulation and Modeling, Theoretische Physik VI, Universität Bayreuth — 2Experimental Physics, Universität des Saarlandes
Red blood cells flowing through capillaries assume a wide variety of different shapes owing to their high deformability. In this work we construct the shape phase diagram of a single red blood cell with a physiological viscosity ratio flowing in a microchannel. We use both experimental in-vitro measurements as well as 3D numerical simulations to complement the respective other one. Two different major shapes are found, namely croissants and slippers. Notably, both shapes show coexistence at low (<1 mm/s) and high velocities (> 3mm/s) while in-between only croissants are stable. This pronounced bistability indicates that RBC shapes are not only determined by system parameters such as flow velocity or channel size, but also strongly depend on the initial conditions.
[1] Guckenberger et al. Soft Matter 14, 2032-2043 (2018)