Regensburg 2019 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 17: Statistical physics of biological systems I (joint session BP/DY)

BP 17.6: Vortrag

Mittwoch, 3. April 2019, 16:30–16:45, H4

Non-equilibrium spatial scaling reveals intrinsic features of the active driving — •Federica Mura, Grzegorz Gradziuk, and Chase Broedersz — Arnold-Sommerfeld-Center for Theoretical Physics and Center for NanoScience, Ludwig-Maximilians-Universität München

Recent experiments indicate non-equilibrium activity in a host of biological systems, including chromosomes, cell membranes, and the cytoplasm. Measuring and quantifying non-equilibrium dynamics in such systems is a major challenge in biophysics, due to their many-body nature and the limited number of variables accessible in an experiment. We investigate what information concerning the system's non-equilibrium state can be extracted by non-invasively tracking a subset of degrees of freedom. To this end, we develop a general, yet simple stochastic model of soft elastic networks with spatially-varying internal driving, representing internal enzymatic force generation. With this model, we determine the scaling behavior of non-equilibrium dynamics from the phase space currents of tracer particles with varying spatial separations in the system. Finally, we will discuss how the non-equilibrium dynamics measured on different length scales can reflect the intrinsic microscopic features of the internal active driving.