Regensburg 2019 – scientific programme

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BP: Fachverband Biologische Physik

BP 18: Cell mechanics II

BP 18.5: Talk

Wednesday, April 3, 2019, 16:00–16:15, H10

Toward theoretical model for cell blebbing — Sebastian Hillringhaus, Gerhard Gompper, and •Dmitry A. Fedosov — Institute of Complex Systems, Forschungszentrum Jülich, Jülich, Germany

Cell blebbing corresponds to the dissociation of cell membrane from the inner cellular network as result of internal stresses. Therefore, it represents the instability of the connection between the membrane and actin cortex. We employ a coarse-grained cell model to study cell blebbing for a number of involved parameters, including membrane rigidity, cytoskeletal stress, and binding strength between the membrane and bulk cytoskeleton. Furthermore, theoretical model for the detachment of bound solid surfaces is extended in order to include the effect of deformable cellular structures on the blebbing process.