Regensburg 2019 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 18: Cell mechanics II

BP 18.7: Hauptvortrag

Mittwoch, 3. April 2019, 16:30–17:00, H10

Physics of epithelial folding — •Guillaume Salbreux — The Francis Crick Institute

The shape of a biological tissue is determined by mechanical stresses acting within the tissue cells. During embryonic morphogenesis, forces generated in the actomyosin cytoskeleton in the cells of epithelia result in cell deformation, cell rearrangements, and 3D bending of the epithelium. To understand tissue morphogenesis, force generation at the cellular scale must be related to flows and deformation occurring at the tissue scale. Here I will discuss how this relation can be captured by a 3D vertex model or by a continuum theory of active surfaces subjected to internal torques. Using this framework, I will discuss epithelial fold formation in the Drosophila wing disc and the formation of pancreatic cancerous tumours.