Regensburg 2019 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 2: Membranes and vesicles I (joint session BP/CPP)
BP 2.8: Vortrag
Montag, 1. April 2019, 12:00–12:15, H10
Structural changes in biomimetic myelin membranes induced by Myelin Basic Protein — •Benjamin Krugmann1,2, Andreas Stadler1, Aurel Radulescu2, Alexandros Koutsioumpas2, and Stephan Förster1,2 — 1Forschungszentrum Jülich JCNS-1, 52428 Jülich, Germany — 2Forschungszentrum Jülich JCNS-MLZ, 85748 Garching, Germany
The myelin sheath plays an important role in nerve signal conduction. It acts as an insulating layer which enables fast signal transport by reducing conduction losses. In demyelinating diseases like multiple sclerosis, this membrane is damaged, which leads to severe problems in nerve conduction. In literature different values for the lipid composition of healthy and modified membranes have been found. Based on these results, we investigate the membrane structure for the respective compositions. As next step we add Myelin Basic Protein (MBP) to the membrane and investigate the induced structural change. Small angle neutron scattering (SANS) and cryo-transmission electron microscopy data show the structure of vesicles with healthy and modified membrane composition and the strong structure change induced by MBP. Neutron Reflectometry (NR) data indicates that MBP interacts differently with healthy and modified myelin membranes.