Regensburg 2019 – scientific programme
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BP: Fachverband Biologische Physik
BP 23: Biomaterials and biopolymers I (joint session BP/CPP)
BP 23.12: Talk
Thursday, April 4, 2019, 12:30–12:45, H10
Collagen gels determine the viscoelastic properties of tissue without hindering the diffusion of the aqueous solvent — Frank Sauer1, Linda Oswald1, Angela Ariza de Schellenberger3, Heiko Tzschätzsch3, •Felix Schrank3, Tony Fischer2, Jürgen Braun4, Claudia T. Mierke2, Rustem Valiullin5, Ingolf Sack3, and Josef A. Käs1 — 1Soft Matter Physics Division,Peter Debye Institute for Soft Matter Physics, Leipzig, Germany — 2Biological Physics Division,Peter Debye Institute for Soft Matter Physics, Leipzig, Germany — 3Department of Radiology, Charité-Universitätsmedizin, Berlin, Germany — 4Institute of Medical Informatics,Charité-Universitätsmedizin, Berlin, Germany — 5Applied Magnetic Resonance, Felix Bloch Institute for Solid State Physics, Leipzig, Germany
Collagen accounts for the major extracellular matrix component in many tissues providing mechanical support for cells. Little is known whether water diffusion interacts with viscoelastic properties of tissues. We are combining highfield MR based diffusion measurements, novel compact tabletop MRE and confocal microscopy in collagen networks of different cross-linking states (untreated versus additional treatment with glutaraldehyde). The MRE-measured shear modulus is sensitive to interactions on the intrafiber level (e.g. fiber stiffness) and is able to depict the pronounced transition from viscous-soft to elastic-rigid gel properties. 3D pore size analysis indicate an unaltered overall network structure and MR based diffusion measurements further allude that there is free extracellular diffusive water transport in connective tissue.