Regensburg 2019 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 24: Cell adhesion and migration, multicellular systems I
BP 24.6: Vortrag
Donnerstag, 4. April 2019, 11:15–11:30, H11
Complex fluid flow and cell polarity in the brain ventricular system — •Christian Westendorf1, Shoba Kapoor2, Yong Wang1, Gregor Eichele2, and Eberhard Bodenschatz1 — 1Max Planck Institute for Dynamics and Self-Organisation, Goettingen, Germany. — 2Max Planck Institute for Biophyscial Chemistry, Goettingen, Germany.
Brain ventricles, that are filled with cerebrospinal fluid (CSF), are coated by specialized epithelial cells each of which carries a bundle of beating cilia. The cilia beats create complex and directional flow patterns that transport CSF and its constituents within the ventricles. The proximal cause of such an organized transport network rests on intricate domains of beating cilia [1]. We used antibody staining and DIC microscopy to explore ciliary polarity and dynamics in the domains and now show that the foundation of the organized flow within and across domains is grounded on the translational and rotational polarities of the cilia bundles. In areas of straight CSF flow, cilia are oriented in a uniform and unidirectional manner. In domains of circular flow, cilia in adjacent cells are oriented in their beating directions so as to generate a circular architecture. In cases where two flow domains are in opposite direction, the beating direction is opposite and changes abruptly over just a few cells. In conclusion, the complex transport network in the ventricle is determined by the polarity properties of the ciliated cells and their cilia.
[1] R. Faubel, C. Westendorf, E. Bodenschatz and G. Eichele, Science 2016, 353(6295) p176-178.