Regensburg 2019 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 31: Cell adhesion and migration, multicellular systems II
BP 31.3: Vortrag
Freitag, 5. April 2019, 10:15–10:30, H10
Stochastic Nonlinear Dynamics of Confined Cell Migration — •David Brückner1, Alexandra Fink2, Christoph Schreiber2, Joachim Rädler2, and Chase Broedersz1 — 1Arnold-Sommerfeld-Center For Theoretical Physics and Center for NanoScience, LMU Munich — 2Faculty of Physics and Center for NanoScience, LMU Munich
In many biological phenomena, cells migrate through confining structured environments. We study how migrating cells overcome physical obstacles in the form of a thin constriction. Specifically, we ask whether such confined migration exhibits emergent stochastic dynamical laws. To this end, we develop two-state micropatterns, consisting of two adhesive sites connected by a thin constriction, allowing the cells to perform repeated stochastic transitions between the sites. For this minimal system, we obtain a large data set of single cell trajectories, enabling us to infer an equation of cell motion, which decomposes the dynamics into deterministic and stochastic contributions. Our data-driven approach reveals that these cells exhibit intricate non-linear migratory dynamics, with qualitatively similar features for cancerous (MDA-MB-231) and non-cancerous (MCF10A) cells. In both cases, the cells drive themselves deterministically into the thin constriction, a process that is sped up by noise. Interestingly, the deterministic dynamics of the cancerous cells exhibits a limit cycle, while the non-cancerous cells show excitable bistable dynamics. Our approach yields a conceptual framework that may be extended to describe active motility on different scales, and in more complex confining environments.