Regensburg 2019 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 31: Cell adhesion and migration, multicellular systems II

BP 31.5: Vortrag

Freitag, 5. April 2019, 10:45–11:00, H10

Placing the power plants: functional crosstalk between mitochondrial homeostasis and active cellular dynamics — •Sufi O. Raja and Christoph F. Schmidt — Third Institute of Physics-Biophysics, Georg-August University of Gottingen, Friedrich-Hund-Platz 1, Gottingen-37077, Germany

Dynamic actomyosin organization is an energy dependent active process and the key to several cellular processes related to shape change and movement. But our knowledge regarding how living cells spatiotemporally control such dynamic organization is still limited. In this context studying the functional role of mitochondrial homeostasis can be a potential target as mitochondria are the cellular energy (Adenosine Tri-Phosphate, ATP) hub and directly regulate the homeostasis of Ca+2 and reactive oxygen species which in turn can potentially regulate actomyosin dynamics locally. On the other hand the mobility of mitochondria is solely determined by the cytoskeleton elements. So, the question is if and how a functional feedback circuit does exists or not. In this context, we are trying to revisit cellular processes like cell adhesion spreading kinetics in the context of mitochondrial homeostasis. How dynamics of the mitochondria (activity/mobility) gets coupled with actomyosin dynamics locally through modulation of local supply of energy and level of small signaling molecules. Lastly, we are also trying to study the response of mitochondrial dynamics during mechanical perturbation of cell to establish a direct connection between cellular energetics and dynamics.