Regensburg 2019 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 6: Poster I

BP 6.19: Poster

Montag, 1. April 2019, 17:30–19:30, Poster B2

Adsorption of Bovine Serum Albumin on Glass Surfaces observed by X-ray Reflectometry — •Annemarie Pfnür¹, Michail Goldes¹, Sarah Höhn², Aldo Roberto Boccaccini², and Tobias Unruh¹ — ¹Institute of Crystallography and Structural Physics, Friedrich-Alexander-Universität Erlangen- Nürnberg (FAU), Staudtstr. 3, 91058 Erlangen, Germany — ²Department of Materials Science and Engineering, Institute for Biomaterials, Friedrich-Alexander-Universität Erlangen- Nürnberg (FAU), Cauerstr. 6, 91058 Erlangen, Germany

Bioactive glass (e.g. 45S5) is used since more than 30 years in bone and dental implants. In contact with liquids soluble silica, calcium phosphate, and sodium ions are released from the surface and a crystalline hydroxyapatite layer on the glass surface is formed which can bond to bone tissue. A basic understanding of the medical compatibility on a molecular level has, however, not been achieved yet.

Thus, we present first X-Ray Reflectivity (XRR) data on protein adsorption on glasses which is intended to mimic the very first step of glass interaction with body fluid and cells after implantation. We were able to detect protein monolayers and determine the thickness and roughness of the protein layer on the angstrom scale. Furthermore, we are sensitive to aging effects of the glass surface, e.g. glass corrosion, which occur when the glass is immersed in water or buffer. The results from bio glass is compared to soda lime and borosilicate glass.