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BP: Fachverband Biologische Physik
BP 6: Poster I
BP 6.19: Poster
Monday, April 1, 2019, 17:30–19:30, Poster B2
Adsorption of Bovine Serum Albumin on Glass Surfaces observed by X-ray Reflectometry — •Annemarie Pfnür1, Michail Goldes1, Sarah Höhn2, Aldo Roberto Boccaccini2, and Tobias Unruh1 — 1Institute of Crystallography and Structural Physics, Friedrich-Alexander-Universität Erlangen- Nürnberg (FAU), Staudtstr. 3, 91058 Erlangen, Germany — 2Department of Materials Science and Engineering, Institute for Biomaterials, Friedrich-Alexander-Universität Erlangen- Nürnberg (FAU), Cauerstr. 6, 91058 Erlangen, Germany
Bioactive glass (e.g. 45S5) is used since more than 30 years in bone and dental implants. In contact with liquids soluble silica, calcium phosphate, and sodium ions are released from the surface and a crystalline hydroxyapatite layer on the glass surface is formed which can bond to bone tissue. A basic understanding of the medical compatibility on a molecular level has, however, not been achieved yet.
Thus, we present first X-Ray Reflectivity (XRR) data on protein adsorption on glasses which is intended to mimic the very first step of glass interaction with body fluid and cells after implantation. We were able to detect protein monolayers and determine the thickness and roughness of the protein layer on the angstrom scale. Furthermore, we are sensitive to aging effects of the glass surface, e.g. glass corrosion, which occur when the glass is immersed in water or buffer. The results from bio glass is compared to soda lime and borosilicate glass.