Regensburg 2019 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 6: Poster I
BP 6.22: Poster
Montag, 1. April 2019, 17:30–19:30, Poster B2
Robust increase in supply by vessel dilation in globally coupled microvasculature — •Felix J. Meigel1, Peter Cha2, Michael P. Brenner2, and Karen Alim1,2 — 1Max Planck Institute for Dynamics and Self-Organization, 37077 Göttingen, Germany — 2Harvard University, Cambridge, MA, U.S.A.
Neuronal activity induces changes in blood flow by locally dilating vessels in the brain microvasculature. How can the local dilation of a single vessel increase flow-based metabolite supply given that flows are globally coupled within microvasculature? Solving the supply dynamics for a microvasculature excerpt, we find one parameter regime to dominate. This regime allows for robust increase in supply independent of the exact position in the network, which we explain analytically. We show how the local coupling of supply in vessels promotes spatial clustering in increased supply by dilation.