Regensburg 2019 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 6: Poster I

BP 6.73: Poster

Montag, 1. April 2019, 17:30–19:30, Poster B2

Theory for active transport by DNA-relaying — •Christian Hanauer and Chase Broedersz — Arnold Sommerfeld Center for Theoretical Physics and Center for NanoScience, Ludwig-Maximilians-Universität, D-80333 München

Robust and faithful segregation of chromosomes is essential for the replication of bacterial cells. In recent years, experiments have identified the biochemical and mechanical properties of the chromosome as key ingredients for active transport in bacterial cells. Intracellular cargoes, such as chromosomal ori, are thought to use chromosome fluctuations to transport themselves along a guiding concentration gradient of DNA-binding ATPases. However, a theory for this DNA-relaying is still lacking. To understand the DNA-relay mechanism, we develop an analytical framework that allows us to calculate the relaying force on the cargo. We test our predictions by Brownian Dynamics simulations. Our analytical model provides insight into how the system parameters determine this active transport mechanism.