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Regensburg 2019 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 9: Computational biophysics

BP 9.6: Vortrag

Dienstag, 2. April 2019, 11:15–11:30, H11

Fine- grained simulation of the microenvironment of vascularized tumors — •Thierry Fredrich1, Edoardo Milotti2, Roberto Chignola3, and Heiko Rieger11Center for Biophysics & Theoretical Physics, Saarland University, D-66123 Saarbrücken — 2Physics Department, Triest University, I-34127 Triest — 3Department of Biotechnology, I-37134 Verona

The road to the understanding of cancer is long and we are just at the beginning, however the life science community provides more and more insight into the underlying processes causing the, not always, deadly modifications of organs, tissue, vasculature, cells, etc. We combined a lattice-free simulation of tumor cells (VBL) with a lattice based blood vessel dynamic simulation (tumorcode) to mimic vascularized solid tumors at tissue scale. We reproduced in vivo measurements of pH and partial oxygen pressure (PO2) obtained by Jain et. al. and observe the formation of different ecological niches at very early stages of tumor growth which could be a source of tumor heterogeneity.
I will present the two models and their combination, and discuss first results.

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