Regensburg 2019 – scientific programme
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BP: Fachverband Biologische Physik
BP 9: Computational biophysics
BP 9.6: Talk
Tuesday, April 2, 2019, 11:15–11:30, H11
Fine- grained simulation of the microenvironment of vascularized tumors — •Thierry Fredrich1, Edoardo Milotti2, Roberto Chignola3, and Heiko Rieger1 — 1Center for Biophysics & Theoretical Physics, Saarland University, D-66123 Saarbrücken — 2Physics Department, Triest University, I-34127 Triest — 3Department of Biotechnology, I-37134 Verona
The road to the understanding of cancer is long
and we are just at the beginning, however the life science community
provides more and more insight into the underlying processes
causing the, not always, deadly modifications of
organs, tissue, vasculature, cells, etc.
We combined a lattice-free simulation of tumor cells (VBL)
with a lattice based blood vessel dynamic simulation (tumorcode)
to mimic vascularized solid tumors at tissue scale.
We reproduced in
vivo measurements of pH and partial oxygen pressure (PO2)
obtained by Jain et. al. and observe the formation of different ecological
niches at very early stages of tumor growth which could be a
source of tumor heterogeneity.
I will present the two models and their combination,
and discuss first results.