Regensburg 2019 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 9: Computational biophysics
BP 9.8: Vortrag
Dienstag, 2. April 2019, 11:45–12:00, H11
Numerical simulations to extract cell viscosity from microfluidic experiments — •Lucas D. Wittwer1, 2, Sebastian Aland2, and Jochen Guck1 — 1BIOTEC, Center for Molecular and Cellular Bioengineering, TU Dresden, Germany — 2Faculty of Informatics / Mathematics, University of Applied Science Dresden, Germany
The mechanical properties of biological cells are promising biomarkers to differentiate for example cell phenotypes, cell states or between healthy and unhealthy cells with applications ranging from research facilities to medical laboratories. Real-time deformability cytometry (RT-DC) allows probing the mechanical characteristics of ~1000 cells/s by imaging the cells when flowing through a microfluidic channel. The observed deformation can be used to infer the mechanical properties. So far, the expected deformation has been analysed theoretically and numerically assuming the cell to be a homogeneous elastic material. Here, we extend the mathematical framework to include the viscosity of the cell based on a fluid-structure interaction (FSI) simulation. In this talk, we present the extended numerical model, compare it with experimental results and illustrate the new possibilities to infer viscosity from real-time measurements in RT-DC.