Regensburg 2019 – scientific programme
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 13: Membranes and Vesicles II (joint session BP/CPP)
CPP 13.3: Talk
Monday, April 1, 2019, 15:30–15:45, H10
X-Ray Reflectivity Investigation of Structure and Kinetics of Photoswitchable Lipid Monolayers — •Jonas Erik Warias1, Svenja Carolin Hövelmann1, Franziska Reise2, Andrea Sartori1, Rajendra Prasad Giri1, Chen Shen3, Thisbe Lindhorst2, Olaf Magnus Magnussen1, and Bridget Mary Murphy1,4 — 1Institut für Experimentelle und Angewandte Physik, University of Kiel, Germany — 2Otto Diels-Institut für Organische Chemie, University of Kiel, Germany — 3Deutsches Elektronen Synchrotron, Hamburg, Germany — 4Ruprecht Heansel Laboratory, University of Kiel, Germany
The mechanical and dynamic properties of phospholipid membranes are of importance for biological functions, such as switching of embedded proteins and cell transportation. In order to investigate these properties we study model systems in which amphiphilic photoswitchable molecules are integrated into Langmuir films of phospholipids. We have modified glycolipids to contain an azobenzene photoswitch between the chain and the head group and successfully embedded those in a monolayer of dipalmitoylphosphatidylcholine (DPPC). This allows us to reversibly change the azobenzene-glycolipid orientation between trans- and cis-conformation by illumination with UV and blue light. We have followed the structural changes in this model membrane and the switching kinetics of the system with Langmuir isotherms and in situ X-ray reflectivity at the LISA diffractometer P08, PETRA III. Strong changes in membrane conformation upon switching have been observed and an additional phase transition has been discovered.